AimArbuscular mycorrhizal symbiosis: The aims of this study were to explore the relationships between sarcopenia, BRI and CVD among elderly adults in China and to determine whether coexistence of sarcopenia and high BRI was associated with a significantly heavier health burden.. Methods: The study used three waves of data from the China health and retirement longitudinal study(CHARLS) in 2011, 2015 and 2018. A total of 6152 participants aged 45 or above were classified into the following groups: neither sarcopenia or high BRI, sarcopenia only, high BRI only, and both sarcopenia and high BRI. Sarcopenia was defined according to the Asian Working Group for Sarcopenia 2019 criteria. CVD was defined as the presence of physician-diagnosed heart disease, diabetes and/or stroke. The associations of BRI and sarcopenia with CVD risk were explored using Cox proportional hazards regression models. Study Design: prospective cohort study. Results: During the 7 years follow-up, 2385 cases(38.8%) with incident CVD were identified. Longitudinal results demonstrated that compared to neither sarcopenia or high BRI, high BRI only(HR:1.22, 95%CI: 1.09, 1.37), and both sarcopenia and high BRI(HR: 1.49, 95%CI: 1.08, 2.07) were associated with higher risk of CVD. In the subgroup analysis, individuals更多 with both sarcopenia and high BRI were more likely to have new onset stroke(HR: 1.93, 95%CI: 1.12, 3.32) and increased risk of multimorbidity(HR: 2.15, 95% CI: 1.14, 4.04). Conclusions: CoexiPLX-4720半抑制浓度stence of sarcopenia and high BRI was associated with higher risk of CVD. Early identification and intervention for sarcopenia and BRI not only allows the implementation of therapeutic strategies, but also provides an opportunity to mitigate the risk of developing CVD.