Background: Alzheimer’s disease(AD)Mexican traditional medicine is an age-related neurodegenerative disorder. Previous studies have indicated that the blueberry(BB) extracts have protective effects on brain function. However, its underlying mechanism remains largely unexplored. Objective: Our research planned to explore the effects and mechanism of BB extracts in improving the learning and memory capacity of AD mice based on the pathway of MEK-ERK. Methods: 3-month-old APP/PS1 transgenic mice were divided into AD+BB, AD, and control(CT) group. Morris water maze test(MWMT) was applied to evaluate the learning and memory capacity. Moreover, the swimming distance and time in the acquisition trial, as well as swimming distance, swimming time, and crossing times in the target quadrant in the probe trial, were recorded. In vitro, the Aβ25-35-injured rat hippocampal neurons were exposed to BB extracts of different concentrations. In addition, the expressions of MEK-ERK-BDNF/UCH-L1 pathway-related genes at the mRNA and protein levels were assessed. Results: Our data showed that the AD mice exhibited weak learning and memory capacity in the acquisition trial and probe trial of the MWMT, while the AD+BB grselleck抑制剂oup exhibited significantly better performance. In the AD group, the expressions of both MEK2 and ERK1/2 at the mRNA and protein levels were significantly elevated, the expression of UCH-L1 at the mRNA level was decreased and the expression of BDNF was increased significantly. With the treatment of BB extracts, the expressions of MEK2 and ERK1/2 were inhibited, and the expressions of UCH-L1 and BDNF at the mRNA level returned to normal. A similar regulate effect of BB extracts on the expressions of UCH-L1 and BDNF was observed. Conclusions: BB extracts might be beneficial for AD by improving the learning and memory capacity. ExcessiTaurine浓度vely activated MEK-ERK pathway and abnormal expressions of BDNF and UCH-L1 might be risk factors for AD.